Primary pulmonary hypertension, cerebrovascular malformation, and lymphoedema feet in a family.

Since Clarke et al. (1927) described primary pulmonary hypertension in two sisters, several families with more than one member involved have been reported (Lange, 1948; Dresdale, Michtom, and Schultz, 1954; van Epps, 1957; Coleman, Edmunds, and Tregillus, 1959; Fleming, 1960; Cahen et al., 1961; van Bogaert et al., 1961; Boiteau and Libanoff, 1963; Melmon and Braunwald, 1963; Parry and Verel, 1966; Kingdon et al., 1966). The present family is interesting because its several members suffered from more than one disease in common.